{"id":1246,"date":"2024-09-19T13:29:18","date_gmt":"2024-09-19T13:29:18","guid":{"rendered":"https:\/\/www.microplanet.at\/?page_id=1246"},"modified":"2024-12-06T09:29:55","modified_gmt":"2024-12-06T08:29:55","slug":"project-5","status":"publish","type":"page","link":"https:\/\/www.microplanet.at\/index.php\/project-5\/","title":{"rendered":"Project 5"},"content":{"rendered":"\n
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Project 5<\/h2>\n\n\n\n

Microbiome Monitoring and Interventions for Human Health<\/strong><\/h2>\n\n\n\n

Microbiome monitoring and precision microbiome modification hold tremendous potential for improving human health. In Project 5, we will focus on disease surveillance for improved public health, and on targeted interventions in inflammatory and metabolic diseases as well as cancer.<\/p>\n\n\n\n

By targeted evaluation of wastewater microbiomes, critical information about the extent and location of communicable diseases and the identity and extent of antibiotic resistance genes will be generated. This targeted surveillance serves both as an early warning system and a quantitative measure of the success of public health interventions that can guide the actions of decision-makers almost in real-time.<\/p>\n\n\n\n

One of the most promising microbiome-based interventions in human health is fecal microbiota transplantation (FMT), which is used successfully to restore microbiomes and ameliorate diverse disease pathologies. We will leverage our clinical FMT facility and large FMT biospecimen repository to evaluate the value of personalized FMTs.<\/p>\n\n\n\n

Finally, we will specifically examine signaling molecules important to the interdomain communication between human host and microbiome to design intervention strategies as a therapeutic strategy for diseases such as inflammatory bowel disease.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Involved KEY RESEARCHERs<\/h3>\n\n\n\n
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andreas bergthaler<\/p>\n\n\n\n

Project Leader<\/p>\n\n\n\n

medical UNIVERSITY of Vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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isabella anderson-wagner<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

UNIVERSITY of Vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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david berry<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

university of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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ruth birner-gr\u00fcnberger<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

technische universit\u00e4t wien (tu wien)<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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thomas b\u00f6ttcher<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

university of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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clarissa campbell<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

center for molecular medicine (cemm, \u00f6aw)<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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holger Daims<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

university of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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gregor gorkiewicz<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

medical university of graz<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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matthias horn<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

university of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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christine moissl-eichinger<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

medical university of graz<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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alexander moschen<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

johannes kepler university linz<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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angela sessitsch<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

austrian institute of technology<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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michael wagner<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

UNIVERSITY of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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wolfgang wanek<\/p>\n\n\n\n

Project Member<\/p>\n\n\n\n

UNIVERSITY of vienna<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n

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InVolved institutions<\/h2>\n<\/div>\n\n\n\n
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work packages in project 5<\/h2>\n<\/div>\n\n\n\n
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Work package 5.1<\/h3>\n\n\n\n

Wastewater Microbiomes for Next-Gen Public Health Monitoring <\/strong><\/p>\n\n\n\n

Targeted monitoring of complex microbiomes has proven to be an extremely useful early warning system for public health. Work Package 5.1 aims to develop the methodology to track the dynamics of bacteria, viruses\/phages, and archaea across an urban sewer system to establish baselines and derivations from wastewater microbiomes that will inform and assess mitigation strategies for public health.<\/p>\n\n\n\n

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More \u2192<\/strong><\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Work package 5.2<\/h3>\n\n\n\n

Microbiome Modification by Fecal Microbiota Transplantation <\/strong><\/p>\n\n\n\n

FMT is an efficient therapy for recurrent Clostridioides difficile infection, but also holds promise in the treatment of inflammatory bowel disease and other complaints. In Work Package 5.2 we will gain a deeper understanding of FMT mechanisms, which will lead to optimized procedures in the future, potentially expanding the applications of microbiome modulatory therapies.<\/p>\n\n\n\n

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Work package 5.3<\/h3>\n\n\n\n

Eavesdropping Interdomain Signals and Modulators <\/strong><\/p>\n\n\n\n

Organisms use chemical signals to coordinate their behavior across cells, tissues and populations. Eavesdropping or intercepting these intradomain chemical messages could provide important cues for outside members to respond adaptively. Work Package 5.3 will identify commonalities and concepts that shape interdomain interactions in microbiomes.<\/p>\n\n\n\n

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More \u2192<\/strong><\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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<\/div>\n\n\n\n
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Read more on Project 1<\/a><\/div>\n\n\n\n
Read more on Project 2<\/a><\/div>\n\n\n\n
Read more on Project 3<\/a><\/div>\n\n\n\n
Read more on Project 4<\/a><\/div>\n\n\n\n
Read more on Project 6<\/a><\/div>\n\n\n\n
Read more on Project 7<\/a><\/div>\n<\/div>\n<\/section>\n<\/div>\n\n\n\n
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Find us on social media<\/p>\n\n\n\n

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\"LinkedIn\"<\/a><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

Project 5 Microbiome Monitoring and Interventions for Human Health Microbiome monitoring and precision microbiome modification hold tremendous potential for improving human health. In Project 5, we will focus on disease surveillance for improved public health, and on targeted interventions in inflammatory and metabolic diseases as well as cancer. By targeted evaluation of wastewater microbiomes, critical […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1246","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/pages\/1246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/comments?post=1246"}],"version-history":[{"count":27,"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/pages\/1246\/revisions"}],"predecessor-version":[{"id":3877,"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/pages\/1246\/revisions\/3877"}],"wp:attachment":[{"href":"https:\/\/www.microplanet.at\/index.php\/wp-json\/wp\/v2\/media?parent=1246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}